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DESCARTES : O. MICHEAU
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Publications

2024

  • Groeneveld CS, Sanchez-Quiles V, Dufour F, Shi M, Dingli F, Nicolle R, Chapeaublanc E, Poullet P, Jeffery D, Krucker C, Maillé P, Vacherot F, Vordos D, Benhamou S, Lebret T, Micheau O, Zinovyev A, Loew D, Allory Y, de Reyniès A, Bernard-Pierrot I, Radvanyi F. Proteogenomic characterization of bladder cancer reveals sensitivity to TRAIL-induced apoptosis in FGFR3-mutated tumors. European Urology Eur Urol. 2024 May;85(5):483-494.
  • Guerrache A, Micheau O. TNF-Related Apoptosis-Inducing Ligand: Non-Apoptotic Signalling. Cells. 2024 Mar 16;13(6):521. doi: 10.3390/cells13060521.

2020-2023

  • Meunier M, Yammine A, Bettaieb A, Plenchette S. Nitroglycerin: a comprehensive review in cancer therapy. Cell Death Dis. 2023 May 12;14(5):323. doi: 10.1038/s41419-023-05838-5.
  • Radoua A, Pernon B, Pernet N, Jean C, Elmallah M, Guerrache A, Constantinescu AA, Hadj Hamou S, Devy J, Micheau O. ptARgenOM – a flexible vector for CRISPR/CAS9 non-viral delivery Small Methods 2023, 7(7): 2300069.
  • Ichim G, Gibert B, Adriouch S, Brenner C, Davoust N, Desagher S, Devos D, Dokudovskaya S, Dubrez L, Estaquier J, Gillet G, Guénal I, Juin PP, Kroemer G, Legembre P, Levayer R, Manon S, Mehlen P, Meurette O, Micheau O, Mignotte B, Nguyen-Khac F, Popgeorgiev N, Poyet JL, Priault M, Ricci JE, Riquet FB, Susin SA, Suzanne M, Vacher P, Walter L, Mollereau B. Keeping Cell Death Alive: An Introduction into the French Cell Death Research Network. 2022 Biomolecules 12(7):901-929.
  • Ghione S, Racoeur C, Mabrouk N, Shan J, Groetz E, Ballot E, Truntzer C, Chouchane L, Végran F, Paul C, Plenchette S, Bettaieb A. Protein Kinase Inhibitor-Mediated Immunoprophylactic and Immunotherapeutic Control of Colon Cancer. Front Immunol. 2022 Apr 28;13:875764. doi: 10.3389/fimmu.2022.875764.
  • Zischler L, Cogo SC, Micheau O, Elifio-Esposito S. Evidence that BJcuL, a C-type lectin from Bothrops jararacussu venom, influences deubiquitinase activity, resulting in the accumulation of anti-apoptotic proteins in two colorectal cancer cell lines. 2022  Int. J. Macromol. 209(Pt A):1205-1210.
  • Airiau K, Vacher P, Micheau O, Prouzet-Mauleon V, Kroemer G, Moosavi MA, Djavaheri-Mergny M. TRAIL Triggers CRAC-Dependent Calcium Influx and Apoptosis through the Recruitment of Autophagy Proteins to Death-Inducing Signaling Complex. 2022 Cells 11(1):57.
  • Abdelkafi-Koubaa Z, ELBini-Dhouib I, Souid S, Jebali J, Doghri R, Srairi-Abid N, Essafi-Benkhadir K, Micheau O, Marrakchi N. Pharmacological Investigation of CC-LAAO, an L-Amino Acid Oxidase from Cerastes cerastes Snake Venom. 2021 Toxins 13(12):904.
  • Bouaouiche S, Ghione S, Sghaier R, Burgy O, Racoeur C, Derangère V, Bettaieb A, Plenchette S.
    Nitric Oxide-Releasing Drug Glyceryl Trinitrate Targets JAK2/STAT3 Signaling, Migration and Invasion of Triple-Negative Breast Cancer Cells. Int J Mol Sci. 2021 Aug 6;22(16):8449.
  • Micheau O, Rizzi M, Smulski C. Editorial: TNFR Superfamily Oligomerization and Signaling. 2021 Front. Cell Dev. Biol. 9:682472.
  • Guérin E, Meunier M, Plenchette S. [IAPs and cancer: The NO strikes back]. Med Sci (Paris). 2021 Jun-Jul;37(6-7):681-683.
  • Dias AMM, Douhard R, Hermetet F, Regimbeau M, Lopez TE, Gonzalez D, Masson S, Marcion G, Chaumonnot K, Uyanik B, Causse SZ, Rieu A, Hadi T, Basset C, Chluba J, Grober J, Guzzo J, Neiers F, Ortega-Deballon P, Demidov ON, Lirussi F, Garrido C. Lactobacillus stress protein GroEL prevents colonic inflammation. J Gastroenterol. 2021 May;56(5):442-455.
  • Montfort A, Bertrand F, Rochotte J, Gilhodes J, Filleron T, Milhès J, Dufau C, Imbert C, Riond J, Tosolini M, Clarke CJ, Dufour F, Constantinescu AA, de França Junior N, Garcia V, Record M, Cordelier P, Brousset P, Rochaix P, Silvente-Poirot S, Therville N, Andrieu-Abadie N, Levade T, Hannun YA, Benoist H, Meyer N, Micheau O, Colacios C, Ségui B. Neutral sphingomyelinase 2 heightens anti-melanoma immune responses and anti-PD-1 therapy efficacy 2021 Cancer Immunol Res. 9(5):568-582.
  • Belkahla H, Constantinescu AA, Gharbi T, Barbault F, Chevillot-Biraud A, Decorse P, Micheau O, Hemadi M*, Ammar S* Grafting TRAIL through either Amino or Carboxylic Groups onto Maghemite Nanoparticles: Influence on Pro-Apoptotic Efficiency 2021 Nanomaterials 11(2), 502.
  • Mabrouk N, Ghione S, Laurens V, Plenchette S, Bettaieb A, Paul C. Senescence and Cancer: Role of Nitric Oxide (NO) in SASP. Cancers (Basel). 2020 May 2;12(5):1145.
  • Teyssier L, Sorci G, Chluba J, Aimé S, Wendehenne D, Lamotte O, Connat JL. Some Plant Defense Stimulators can induce IL-1β production in human immune cells in vitro. Toxicol Rep. 2020 Feb 19;7:413-420.
  • Cardoso Alves L, Corazza N, Micheau O, Krebs P. The multifaceted role of TRAIL signaling in cancer and immunity. 2020 FEBS J 288(19):5530-5554.
  • Vanbervliet-Defrance B, Delaunay T, Daunizeau T, Kepenekian V, Glehen O, Weber K, Estornes Y, Ziverec A, Djemal L, Delphin M, Lantuéjoul S, Passot G, Grégoire M, Micheau O, Blanquart C, Renno T, Fonteneau JF, Lebecque S, Mahtouk K. Cisplatin unleashes Toll-like receptor 3-mediated apoptosis through the downregulation of c-FLIP in malignant mesothelioma. 2020 Cancer Letters, 472:29-39.
  • Ghione S, Mabrouk N, Paul C, Bettaieb A, Plenchette S. Protein kinase inhibitor-based cancer therapies: Considering the potential of nitric oxide (NO) to improve cancer treatment. Biochem Pharmacol. 2020 Jun;176:113855. doi: 10.1016/j.bcp.2020.113855.
  • Elmallah MIY, Cogo S, Constantinescu AA, Elifio-Esposito S, Abdelfattah MS, Micheau O. Marine Actinomycetes-Derived Secondary Metabolites Overcome TRAIL-Resistance via the Intrinsic Pathway through Downregulation of Survivin and XIAP. 2020 Cells 9(8):E1760.

2015-2019

  • Elmallah MIY, Micheau O. Epigenetic Regulation of TRAIL Signaling: Implication for Cancer Therapy. 2019 Cancers, This article belongs to the Special Issue TRAIL Signaling in Cancer Cells
  • Bouaouiche S, Magadoux L, Dondaine L, Reveneau S, Isambert N, Bettaieb A, Jeannin JF, Laurens V, Plenchette S. Glyceryl trinitrate‑induced cytotoxicity of docetaxel‑resistant prostatic cancer cells is associated with differential regulation of clusterin. Int J Oncol. 2019 Apr;54(4):1446-1456.
  • Al Azzaz J, Rieu A, Aires V, Delmas D, Chluba J, Winckler P, Bringer MA, Lamarche J, Vervandier-Fasseur D, Dalle F, Lapaquette P, Guzzo J. Resveratrol-Induced Xenophagy Promotes Intracellular Bacteria Clearance in Intestinal Epithelial Cells and Macrophages. Front Immunol.2019 Jan 14;9:3149.
  • Belkahla H, Mazario E, Plan Sangnier A, Lomas JS, Gharbi T, Ammar S, Micheau O*, Wilhem C*, Hemadi M* TRAIL acts synergistically with iron oxide nanoclusters-mediated magneto- and photothermia. (* co-corresponding). 2019 Theranostics 9(20):5924-5936
  • Dubuisson A, Favreau C, Fourmaux E, Lareure S, Rodrigues-Saraiva R, Pellat-Deceunynck C, El Alaoui S, Micheau O. Generation and characterization of novel anti-DR4 and anti-DR5 antibodies developed by genetic immunization. 2019 Cell Death Dis.10(2):101.
  • Belkahla H, Haque A, Revzin A, Gharbi T, Constantinescu AA, Micheau O*, Hemadi M, Ammar S* Coupling TRAIL to iron oxide nanoparticles increases its apoptotic activity on HCT116 and HepG2 cells. Effect of the magnetic core size. . (* co-corresponding). 2019 JOIN 2:55
  • Brown P; RELISH Consortium (Micheau O.), Zhou Y. Large expert-curated database for benchmarking document similarity detection in biomedical literature search. 2019 Database (Oxford) baz085
  • Alkurdi L, Virard F, Vanbervliet B, Weber K, Toscano F, Bonnin M, Le Stang N, Lantuejoul S, Micheau O, Renno T, Lebecque S, Estornes Y. Release of c-FLIP brake selectively sensitizes human cancer cells to TLR3-mediated apoptosis. 2018 Cell Death Dis. 9(9):874.
  • Romagny S, Bouaouiche S, Lucchi G, Ducoroy P, Bertoldo JB, Terenzi H, Bettaieb A, Plenchette S. S-Nitrosylation of cIAP1 Switches Cancer Cell Fate from TNFα/TNFR1-Mediated Cell Survival to Cell Death. Cancer Res. 2018 Apr 15;78(8):1948-1957.
  • Mennetrier L, Lopez T, Pruvot B, Yousfi N, Armant O, Hazhaz H, Lhuissiez V, Garrido C, Chluba zHSF1 modulates zper2 expression in zebrafish embryos. J. Chronobiol Int. 2018 Jul;35(7):1008-1015.
  • Vial J, Royet A, Cassier P, Tortereau A, Dinvaut S, Maillet D, Gratadou-Hupon L, Creveaux M, Sadier A, Tondeur G, Léon S, Depaepe L, Pantalacci S, De la Fouchardiere A, Micheau O, Dalle S, Laudet V, Mehlen P, Castets M. The Ectodysplasin Receptor EDAR acts as a tumor suppressor in melanoma by conditionally inducing cell death. Cell Death Differ. 26(3):443-454.
  • Micheau O. Regulation of TNF-Related Apoptosis-Inducing Ligand Signaling by Glycosylation. 2018 Int. J Mol. Sci. 19(3). pii: E715 MDPI.
  • Chekkat N, Lombardo CM, Seguin C, Lechner MC, Dufour F, Nominé Y, De Giorgi M, Frisch B, Micheau O, Guichard G, Altschuh D, Fournel S. Relationship between the agonist activity of synthetic ligands of TRAIL-R2 and their cell surface binding modes. 2018 Oncotarget, e24526.
  • Dubuisson A, Micheau O. Antibodies and Derivatives Targeting DR4 and DR5 for Cancer Therapy. 2017 Antibodies, 6(4), 16. MDPI.
  • Bettaieb A, Paul C, Plenchette S, Shan J, Chouchane L, Ghiringhelli F. Precision medicine in breast cancer: reality or utopia? J Transl Med. 2017 Jun 17;15(1):139. doi: 10.1186/s12967-017-1239-z.
  • Teyssier L, Colussi J, Delemasure S, Chluba J, Wendehenne D, Lamotte O, Connat JL. Inflammatory Effects of the Plant Protection Product Stifenia (FEN560) on Vertebrates. Front Public Health. 2017 Apr 24;5:74.
  • Micheau O. Posttranslational Modifications and Death Receptor Signalling. 2017 Resistance to Targeted Anti-Cancer Therapeutics book (Ed. O Micheau), pp247-290. Chapter.Acces to the BOOK.
  • Belkahla H, Herlem G, Picaud F, Gharbi T, Hémadi M, Ammar S, Micheau O. TRAIL-NP hybrids for cancer therapy: A review. 2017 Nanoscale, 9(18):5755-5768.
  • Glorian V, Allegre J, berthelet J, Dumetier B, Betanquoi PM, Droin N, Kayaci C, Cartier J, Gemble S, Garcion G, Gonzalez D, Boidot R, Garrido C, Micheau O, Solary E, Dubrez L. cIAP1-mediated E2F1 stabilization and transcriptional activation involve K63-poly-ubiquitination. 2017 Cell Death Dis., 8(5):e2816 / 9(8):785.
  • Dufour F, Rattier T, Constantinescu AA, Zischler L, Morlé A, Ben Mabrouk H, Humblin E, Jacquemin G, Szegezdi E, Delacote F, Marrakchi N, Guichard G, Gharbi T, Pellat-Deceunynck C, Vacher P, Legembre P, Garrido C, Micheau O. TRAIL receptor gene editing unveils TRAIL-R1 as a master player of apoptosis induced by TRAIL and ER stress. 2017 Oncotarget. 8(6), pp 9974-9985.
  • Bettaieb A, Paul C, Plenchette S. Exploration of Fas S-Nitrosylation by the Biotin Switch Assay. Methods Mol Biol. 2017;1557:199-206.
  • Constantinescu AA, Morlé A, Micheau O. Immunoprecipitation of Death Inducing Signaling Complex by Caspase-8. 2017 Methods Mol Biol. 1557:19-31.
  • Dufour F, Rattier T, shirley S, Picarda G, Morlé A, Zakaria AB, Marcion G, Causse S, Szegezdi E, Zajonc DM, Seigneuric R, Guichard G, Picaud F, Herlem G, Garrido C, Schneider P, Benedict CA, Micheau O. N-glycosylation regulates cell death induced by mouse TRAIL-R and human TRAIL-R1. 2017 Cell Death Differ. 24(3), pp 500-510.
  • Elmallah MIY, Micheau O., Eid MAG, Hebishy AMS, Abdelfattah MS Marine actinomycete crude extracts with potent TRAIL-resistance overcoming activity against breast cancer cells. 2017 Oncol Rep. 37(6), pp 3635-42.
  • Micheau O. FLIP. In: Marshall JL (ed.). 2016 Cancer Therapeutic Targets. pp881-891. Springer, New York
  • Plenchette S, Romagny S, Laurens V, Bettaieb A. [NO and cancer: itinerary of a double agent]. Med Sci (Paris). 2016 Jun-Jul;32(6-7):625-33.
  • Aoudia N, Rieu A, Briandet R, Deschamps J, Chluba J, Jego G, Garrido C, Guzzo J. Biofilms of Lactobacillus plantarum and Lactobacillus fermentum: Effect on stress responses, antagonistic effects on pathogen growth and immunomodulatory properties. Food Microbiol. 2016 Feb;53(Pt A):51-9. doi: 10.1016/j.fm.2015.04.009.
  • Bouaouiche S, Dubrez L, Bettaieb A, Plenchette S. IAPs: Mediators of Oncogenesis and Targets for Anticancer Therapy. Crit Rev Oncog. 2016;21(5-6):399-411.
  • Abassi H, Ayed-Boussema I, Shirley S, Abid S, Bacha H, Micheau O. The mycotoxin zearalenone enhances cell proliferation, colony formation and promotes cell migration in the human colon carcinoma cell line HCT116. 2016 Toxicol Lett. 254, pp 1-7.
  • Zakaria AB, Guillaume YC, Picaud F, Andre C, Gharbi T, Micheau O, Herlem G. Enhanced DR5 binding capacity of nanovectorized TRAIL compared to its cytotoxic version by affinity chromatography and molecular docking studies. 2016 J of Mol Recognition. 29(9), pp 406-414.
  • Ben Mabrouk H, Zouari-Kessentini R, Montassar F, Abdelkefi-Koubaa Z, Messaadi E, Guillonneau X, El Ayeb M, Srairi-Abid N, Luis J, Micheau O and Marrakchi N. CC5 and CC8, two homologous disintegrins from Cerastes cerastes venom, inhibit in vitro and ex vivo angiogenesis. 2016 Int J of Biol Mol. 86, pp 670-680.
  • Elmallah M.I.Y and Micheau O. Marine Drugs Regulating Apoptosis Induced by Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL). 2015 Mar. Drugs, 13(11), pp6884-6909.
  • Plenchette S, Romagny S, Laurens V, Bettaieb A. S-Nitrosylation in TNF superfamily signaling pathway: Implication in cancer. Redox Biol. 2015 Dec;6:507-515.
  • Plenchette S. Role Of S-Nitrosylation In The Extrinsic Apoptotic Signalling Pathway In Cancer. Redox Biol. 2015 Aug;5:415.
  • Yousfi N, Pruvot B, Lopez T, Magadoux L, Franche N, Pichon L, Salvadori F, Solary E, Garrido C, Laurens V, Chluba J. The impact of tumor nitric oxide production on VEGFA expression and tumor growth in a zebrafish rat glioma xenograft model. PLoS One. 2015 Mar 13;10(3):e0120435.
  • Marsolier J, Perichon M, DeBarry JD, Villoutreix BO, Chluba J, Lopez T, Garrido C, Zhou XZ, Lu KP, Fritsch L, Ait-Si-Ali S, Mhadhbi M, Medjkane S, Weitzman JB. Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation. Nature. 2015 Apr 16;520(7547):378-82.
  • Legembre P, Micheau O, Segui B. Chemotherapy with ceramide in TNBC. Oncoscience 2(10):817-8.
  • Levade T, Andrieu-Abadie N, Micheau O, Legembre P, Segui B. Sphingolipids modulate the epithelial–mesenchymal transition in cancer. 2015 Cell Death Discovery 1:15001.
  • Zakaria AB, Picaud F, Duverger E, Devaux X, Delabrousse E, Gharbi T, Micheau O, Herlem G. Nanovector Formation by Functionalization of TRAIL Ligand on Single-walled Carbon Nanotube: Experimental and Theoretical Evidences. 2015 Chem. Phys. Lett, 633, pp 273-281.
  • Iessi E, Zischler L, Etringer A, Bergeret M, Morlé A, Jacquemin G, Morizot A, Shirley S, Lalaoui N, Elifio_esposito SL, Fais S, Garrido C, Solary E, Micheau O. Death receptor-induced apoptosis signalling regulation by Ezrin is cell type dependent and occurs in a DISC-independent manner in colon cancer cells. 2015 PLoS ONE, 10(5): e126526.
  • Zakaria AB, Picaud F, Rattier T, Pudlo M, Dufour F, Saviot L, Chassagnon R, Lherminier J, Gharbi T, Herlem G* and Micheau O*. Nanovectorization of TRAIL with single wall carbon nanotubes enhances tumor cell killing. 2015 Nano Letters 15 (2), pp 891–895 (equal contribution).
  • Morle A, Garrido C and Micheau O. Hyperthermia restores apoptosis induced by death receptors through aggregation-induced c-FLIP cytosolic depletion. 2015 Cell Death Dis. 6, e1633.

2010-2014

  • Edmond V, Dufour F, Poiroux G, Shoji K, Malleter M, Fouqué A, Tauzin S, Rimokh R, Sergent O, Penna A, Dupuy A, Levade T, Theret N, Micheau O, Ségui B, Legembre P. Downregulation of ceramide synthase-6 during epithelial-to-mesenchymal transition reduces plasma membrane fluidity and cancer cell motility. 2014 Oncogene 34(8):996-1005.
  • Rieu A, Aoudia N, Jego G, Chluba J, Yousfi N, Briandet R, Deschamps J, Gasquet B, Monedero V, Garrido C, Guzzo J. The biofilm mode of life boosts the anti-inflammatory properties of Lactobacillus. Cell Microbiol. 2014 Dec;16(12):1836-53.
  • de Thonel A, Hazoumé A, Kochin V, Isoniemi K, Jego G, Fourmaux E, Hammann A, Mjahed H, Filhol O, Micheau O, Rocchi P, Mezger V, Eriksson JE, Rangnekar VM, Garrido C. Regulation of the proapoptotic functions of prostate apoptosis response-4 (Par-4) by casein kinase 2 in prostate cancer cells. 2014 Cell Death Dis. 5:e1016.
  • Micheau O, Shirley S, Morizot A. TRAIL receptor-induced Regulation : An Update to our deadly DISCussion. 2014 Topics in Anti-Cancer Research, Dr Atta-ur-Rhaman & Khurshid Zaman (Ed.), Vol. 3, 2014, 3-36. Link to Chapter
  • Magadoux L, Isambert N, Plenchette S, Jeannin JF, Laurens V. Emerging targets to monitor and overcome docetaxel resistance in castration resistant prostate cancer. Int J Oncol. 2014 Sep;45(3):919-28.
  • Micheau O, Shirley S, Dufour F. Death receptors as targets in cancer. 2013 Br J Pharmacol. 169(8):1723-44.
  • Estornes Y, Micheau O, Renno T, Lebecque S. Dual Role of TLR3 in Inflammation and Cancer Cell Apoptosis. 2013 Oncogene and Cancer – From Bench to Clinic, Dr. Yahwardiah Siregar (Ed.), ISBN: 978-953-51-0858-0, InTech, DOI: 10.5772/54772.
  • Wettstein G, Bellaye PS, Kolb M, Hammann A, Crestani B, Soler P, Marchal-Somme J, Hazoume A, Gauldie J, Gunther A, Micheau O, Gleave M, Camus P, Garrido C, Bonniaud P. Inhibition of HSP27 blocks fibrosis development and EMT features by promoting Snail degradation. 2013 FASEB J. 27(4):1549-60.
  • Shirley S and Micheau O Targeting c-FLIP in cancer. 2013 Cancer Letters 332(2):141-50.
  • Somasekharan SP, Koc M, Morizot A, Micheau O, Sorensen PH, Gaide O, Andera L, Martinou JC. TRAIL promotes membrane blebbing, detachment and migration of cells displaying a dysfunctional intrinsic pathway of apoptosis. 2013 Apoptosis 18(3):324-36.
  • Jennewein C, Karl S, Baumann B, Micheau O, Debatin KM, Fulda S. Identification of a novel pro-apoptotic role of NF-κB in the regulation of TRAIL- and CD95-mediated apoptosis of glioblastoma cells. 2012 Oncogene. 31(11):1468-74.
  • Marivin A, Berthelet J, Plenchette S, Dubrez L. The Inhibitor of Apoptosis (IAPs) in Adaptive Response to Cellular Stress. Cells. 2012 Oct 10;1(4):711-37.
  • Cock-Rada AM, Medjkane S, Janski N, Yousfi N, Perichon M, Chaussepied M, Chluba J, Langsley G, Weitzman JB. SMYD3 promotes cancer invasion by epigenetic upregulation of the metalloproteinase MMP-9. Cancer Res. 2012 Feb 1;72(3):810-20.
  • Wettstein G, Bellaye PS, Micheau O, Bonniaud P. Small heat shock proteins and the cytoskeleton: an essential interplay for cell integrity? 2012 Int J Biochem Cell Biol. 19(9):1482-94.
  • Micheau O, Dufour F, Walczak H. Thiocolchicoside a semi-synthetic derivative of the Glory Lily: a new weapon to fight metastatic bone resorption? 2012 Br J Pharmacol. 44(10):1680-6.
  • Estornes Y, Toscano F, Virard F, Jacquemin G, Pierrot A, Vanbervliet B, Bonnin M, Lalaoui N, Mercier-Gouy P, Pacheco Y, Salaun B, Renno T, Micheau O, Lebecque S. dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8. 2012 Cell Death Differ. 19(9):1482-94.
  • Jacquemin G, Granci V, Gallouet AS, Lalaoui N, Morlé A, Iessi E, Morizot A, Garrido C, Guillaudeux T, Micheau O Quercetin-mediated Mcl-1 and survivin downregulation restores TRAIL-induced apoptosis in Non-Hodgkin B-Lymphoma. 2012 Haematologica 97(1):38-46.
  • Cartier J, Berthelet J, Marivin A, Gemble S, Edmond V, Plenchette S, Lagrange B, Hammann A, Dupoux A, Delva L, Eymin B, Solary E, Dubrez L. Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription. J Biol Chem. 2011 Jul 29;286(30):26406-17.
  • Pruvot B, Jacquel A, Droin N, Auberger P, Bouscary D, Tamburini J, Muller M, Fontenay M, Chluba J, Solary E. Leukemic cell xenograft in zebrafish embryo for investigating drug efficacy. Haematologica. 2011 Apr;96(4):612-6.
  • Shirley S, Morizot A and Micheau O Regulating TRAIL Receptor-Induced Cell Death at the Membrane : A Deadly Discussion. 2011 Recent Pat Anticancer Drug Discov. 6(3):311-23.
  • Lalaoui N, Morlé A, Mérino D, Jacquemin G, Iessi E, Morizot A, Shirley S, Robert B, Solary E, Garrido C, Micheau O TRAIL-R4 promotes tumor growth and resistance to apoptosis in cervical carcinoma HeLa cells through AKT. 2011 PLoS ONE 6(5):e19679.
  • El Fajoui Z, Toscano F, Jacquemin G, Abello J, Scoazec JY, Micheau O, Saurin JC Oxaliplatin Sensitizes Human Colon Cancer Cells to TRAIL through JNK-Dependent Phosphorylation of Bcl-xL. 2011 Gastroenterology ;141(2):663-73.
  • Morizot A, Merino D, Lalaoui N, Granci V, Jacquemin G, Lanneau D, Iessi L, Solary E, Chauffert B, Saas P, Garrido C, Micheau O Chemotherapy overcomes TRAIL-R4-mediated TRAIL resistance at the DISC level. 2011 Cell Death Differ. 18(4):700-11.
  • Rérole AL, Gobbo J, Schmitt E, Pais de Barros JP, Lanneau D, De Thonel A, Hammann A, Fourmaux E, Deminov O, Micheau O, Lagrost L, Colas P, Kroemer G and Garrido C. Peptides and aptamers targeting HSP70: a novel approach for anti-cancer chemotherapy. 2011 Cancer Res. 71(2):484-95.
  • Shirley S. and Micheau O The heme oxygenase-1 and c-FLIP in acute myeloid leukemias: two non-redundant but mutually exclusive cellular safeguards protecting cells against TNF-induced cell death? 2010 Oncotarget. 1(5):317-9.
  • Pruvot B, Laurens V, Salvadori F, Solary E, Pichon L, Chluba J. Comparative analysis of nonaspanin protein sequences and expression studies in zebrafish. Immunogenetics. 2010 Oct;62(10):681-99.
  • Jacquemin G, Shirley S, Micheau O Combining naturally occurring polyphenols with TNF-related apoptosis-inducing ligand: a promising approach to kill resistant cancer cells? 2010 Cell Mol Life Sci. 67(18):3115-30.
  • Pavet V, Beyrath J, Pardin C, Morizot A, Lechner MC, Briand JP, Wendland M, Maison W, Fournel S, Micheau O, Guichard G, Gronemeyer H Multivalent DR5 peptides activate the TRAIL death pathway and exert tumoricidal activity in vivo. 2010 Cancer Res 70(3):1101-1110.
  • Fraszczak J, Trad M, Janikashvili N, CathelinD, Lakomy D, Granci V, Morizot A, Audia S, Micheau O, Lagrost L, Katsanis E, Solary E, Larmonier N, Bonnotte B Peroxynitrite-Dependent Killing of Cancer Cells and Presentation of Released Tumor Antigens by Activated Dendritic Cells. J Immunol. 2010 ;184(4):1876-84.

2005-2009

  • Lalaoui N, Audo R, Morel J, Micheau O, Hahne M Where ends the TRAIL in arthritis? 2009 Rheumatology Reports 1(1):32-36.
  • Lepiller S, Franche N, Solary E, Chluba J, Laurens V. Comparative analysis of zebrafish nos2a and nos2b genes. Gene. 2009 Sep 15;445(1-2):58-65.
  • Jacquel A, Benikhlef N, Paggetti J, Lalaoui N, Guery L, Dufour EK, Ciudad M, Racoeur C, Micheau O, Delva L, Droin N, Solary E CSF-1-induced oscillations in PI3K/AKT are required for caspase activation in monocytes undergoing differentiation into macrophages. 2009 Blood 114(17): 3633-3641.
  • Rushworth SA, Micheau O Molecular crosstalk between TRAIL and natural antioxidants in the treatment of cancer. 2009 Br J Pharmacol. 157(7):1186-1188.
  • Kassahn D, Nachbur U, Conus S, Micheau o, Schneider P, Simon H-U, Brunner T Distinct requirements for activation-induced cell surface expression of preformed Fas/CD95 ligand and cytolytic granule markers in T cells. 2009 Cell Death Differ. 16(1):115-124.
  • Ndozangue-Touriguine O, Sebbagh M, Mérino D, Micheau O, Bertoglio J, Bréard J A mitochondrial block and expression of XIAP lead to resistance to TRAIL-induced apoptosis during progression to metastasis of a colon carcinoma. 2008 Oncogene 27(46):6012-22.
  • Jeudy G, Salvadori F, Chauffert B, Solary E, Vabres P, Chluba J. Polyethylenimine-mediated in vivo gene transfer of a transmembrane superantigen fusion construct inhibits B16 murine melanoma growth. Cancer Gene Ther. 2008 Nov;15(11):742-9.
  • Zhuravleva J, Solary E, Chluba J, Bastie JN, Delva L. A role for the transcription intermediary factor 2 in zebrafish myelopoiesis. Exp Hematol. 2008 May;36(5):559-67.
  • LaCasse EC, Mahoney DJ, Cheung HH, Plenchette S, Baird S, Korneluk RG. IAP-targeted therapies for cancer. Oncogene. 2008 Oct 20;27(48):6252-75.
  • Mahoney DJ, Cheung HH, Mrad RL, Plenchette S, Simard C, Enwere E, Arora V, Mak TW, Lacasse EC, Waring J, Korneluk RG. Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation. Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11778-83.
  • Cheung HH, Plenchette S, Kern CJ, Mahoney DJ, Korneluk RG. The RING domain of cIAP1 mediates the degradation of RING-bearing inhibitor of apoptosis proteins by distinct pathways. Mol Biol Cell. 2008 Jul;19(7):2729-40.
  • Travert M, Ame-Thomas P, Pangault C, MorizotA, Micheau O, Semana G, Lamy T, Fest T, Tarte K, Guillaudeux T CD40 Ligand Protects from TRAIL-Induced Apoptosis in Follicular Lymphomas through NF-kappa B Activation and Up-Regulation of c-FLIP and Bcl-xL. 2008 J. Immunol. 181(2):1001-1011.
  • Toscano F, El Fajoui Z, Gay F, Lalaoui N, Parmentier B, Chayvialle JA, Scoazec JY, Micheau O, Abello J,Saurin JC p53-mediated up-regulation of DcR1 impairs oxaliplatin/TRAILinduced synergistic anti-tumour potential in colon cancer cells. 2008 Oncogene 27(30):4161-71.
  • Mérino D, Lalaoui N, Morizot A, Solary E, Micheau O TRAIL in cancer therapy: current and future challenges. 2007 Expert Opin. Ther. Targets 11(10), 1299-1314.
  • Plenchette S, Cheung HH, Fong WG, LaCasse EC, Korneluk RG. The role of XAF1 in cancer. Curr Opin Investig Drugs. 2007 Jun;8(6):469-76.
  • Brahim S, Prévotat L, Yatouji S, Mérino D, Cortier M, Rébé C, Micheau O, Kenani A, Bettaieb A Deglycosylated Bleomycin induces apoptosis in Lymphoma cell via c-jun NH2-terminal kinase but not reactiveoxygen species. 2007 Biochem Pharmacol. 74(10), 1445-55.
  • Arora V, Cheung HH, Plenchette S, Micali OC, Liston P, Korneluk RG. Degradation of survivin by the X-linked inhibitor of apoptosis (XIAP)-XAF1 complex. J Biol Chem. 2007 Sep 7;282(36):26202-9.
  • Micali OC, Cheung HH, Plenchette S, Hurley SL, Liston P, LaCasse EC, Korneluk RG. Silencing of the XAF1 gene by promoter hypermethylation in cancer cells and reactivation to TRAIL-sensitization by IFN-beta. BMC Cancer. 2007 Mar 21;7:52. doi: 10.1186/1471-2407-7-52.
  • Lepiller S, Laurens V, Bouchot A, Herbomel P, Solary E, Chluba J. Imaging of nitric oxide in a living vertebrate using a diamino-fluorescein probe. Free Radic Biol Med. 2007 Aug 15;43(4):619-27.
  • Grobner S Adkins I, Schulz S, Richter K, Borgmann S, Wesselborg S, Ruckdeschel K, Micheau O, Autenrieth IB, Catalytically active Yersinia outer protein P induces cleavage of RIP and caspase-8 at the level of the DISC independently of death receptors in dendritic cells. 2007 Apoptosis 12(10):1813-25.
  • Kummer* JA, Micheau* O, Schneider P, Bovenschen N, Broekhuizen R, Quadir R, Strik MCL, Hack E, Tschopp J, Ectopic expression of the serine protease inhibitor PI9 modulates death receptor -mediated apoptosis. 2007 Cell Death Differ. 14(8), 1486-96. Equal contribution*.
  • Meurette O, Huc L, Rebillard A, Le Moigne G, Merino D, Micheau O, Lagadic-Gossmann D, Dimanche Boitrel MT TRAIL induces a RIP1 (Receptor-Interacting Protein 1)-dependent and caspase dependent necrosis-like cell death under acidic extra-cellular conditions (pH 6.5). 2007 Cancer Res. 67(1), 218-226.
  • Rébé C, Cathelin S, Launay S, Filomenko R, Prévotat L, L’Ollivier C, Gyan E, Micheau O, Grant S, Dubart-Kupperschmitt A, Fontenay M, Solary E, Caspase-8 prevents sustained activation of NF-κB in monocytes undergoing macrophagic differentiation. 2007 Blood, 109(4):1442-50.
  • Mérino D, Lalaoui N, Morizot A, Solary E, Schneider P, Micheau O, Differential inhibition of TRAIL-induced apoptosis by DcR1 and DcR2. 2006 Mol. Cell. Biol. 26(19):7046-7055.
  • Burron N, Micheau O, Lafontaine PO, Creuzot-Gracher C, Solary E Differential mechanisms of conjunctival cell death induction by ultraviolet and benzalkonium chloride. 2006 IOVS. 47(10):4221-4230.
  • Micheau O, Cellular FLICE-inhibitory Protein: An Update. 2006 Apoptosis and Cancer Therapy. Ed K-M Debatin and S Fulda. Wiley-VCH Verlag GmbH & Co. KGaA, 120-155. Wiley-VCH
  • Lemarie A, Morzadec C, Mérino D, Micheau O, Fardel O and Vernhet L, Arsenic trioxide inhibits macrophagic differentiation at clinically relevant concentrations through NF-kB-related survival pathway downregulation. 2006 J Pharmacol Exp Ther. 316(1):304-14.
  • Salon C, Eymin B, Micheau O, Chaperot L, Plumas J, Brambilla C, Brambilla E, Gazzeri S, E2F1 induces apoptosis and sensitize human cell lung carcinoma through specific downregulation of the FLIP short protein isoform. 2006 Cell Death Differ. 13(2):260-72.
  • Ponnelle T, Chapusot C, Martin L, Bouvier AM, Plenchette S, Faivre J, Solary E, Piard F. Cellular localisation of survivin: impact on the prognosis in colorectal cancer. J Cancer Res Clin Oncol. 2005 Aug;131(8):504-10. doi: 10.1007/s00432-005-0682-z.

2000-2004

  • Delmas D, Rebe C, Micheau O, Athias A, Gambert P, Grazide S, Laurent G, Latruffe N, Solary E. Redistribution of CD95, DR4 and DR5 in rafts accounts for the synergistic toxicity of resveratrol and death receptor ligands in colon carcinoma cells. 2004 Oncogene. 23(55):8979-86.
  • Plenchette S, Filomenko R, Logette E, Solier S, Buron N, Cathelin S, Solary E. Analyzing markers of apoptosis in vitro. Methods Mol Biol. 2004;281:313-31. doi: 10.1385/1-59259-811-0:313.
  • Jault C, Pichon L, Chluba Toll-like receptor gene family and TIR-domain adapters in Danio rerio. J. Mol Immunol. 2004 Jan;40(11):759-71.
  • Plenchette S, Cathelin S, Rébé C, Launay S, Ladoire S, Sordet O, Ponnelle T, Debili N, Phan TH, Padua RA, Dubrez-Daloz L, Solary E. Translocation of the inhibitor of apoptosis protein c-IAP1 from the nucleus to the Golgi in hematopoietic cells undergoing differentiation: a nuclear export signal-mediated event. Blood. 2004 Oct 1;104(7):2035-43.
  • Micheau O., Mérino D., Controlling TRAIL-mediated caspase-3 activation. 2004 Leukemia, 18(10):1578-80.
  • Micheau O., To die or not to die ? Un modele de la signalisation dichotomique de TNF-R1. 2004 Médecine et Sciences, 20 (2) :153-5.
  • Micheau O., Criblage postgénomique par ARNi chez les mammifères? 2004 Médecine et Sciences (Brève), 20 (2) :163.
  • Ponnelle T, Chapusot C, Martin L, Bonithon-Kopp C, Bouvier AM, Plenchette S, Rageot D, Faivre J, Solary E, Piard F. Subcellular expression of c-IAP1 and c-IAP2 in colorectal cancers: relationships with clinicopathological features and prognosis. Pathol Res Pract. 2003;199(11):723-31.
  • Vautier D, Hemmerlé J, Vodouhe C, Koenig G, Richert L, Picart C, Voegel JC, Debry C, Chluba J, Ogier J 3-D surface charges modulate protrusive and contractile contacts of chondrosarcoma cells. Cell Motil Cytoskeleton. 2003 Nov;56(3):147-58.
  • Micheau O. and J. Tschopp Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. 2003 Cell 114(2) :181- 190.
  • Micheau O. Cellular FLICE-inhibitory protein : an attracive therapeutic target ?. 2003 Expert Opin. Ther. Targets. 7(4):559-73.
  • Parcellier A, Schmitt E, Gurbuxani S, Seigneurin-Berny D, Pance A, Chantôme A, Plenchette S, Khochbin S, Solary E, Garrido C. HSP27 is a ubiquitin-binding protein involved in I-kappaBalpha proteasomal degradation. Mol Cell Biol. 2003 Aug;23(16):5790-802.
  • Bettaieb A, Dubrez-Daloz L, Launay S, Plenchette S, Rébé C, Cathelin S, Solary E. Bcl-2 proteins: targets and tools for chemosensitisation of tumor cells. Curr Med Chem Anticancer Agents. 2003 Jul;3(4):307-18.
  • Viard-Leveugle I., Bullani R., Meda P., Micheau O., Limat A., Saurat J.H., Tschopp J. and French L.E. Intracellular localization of keratinocyte Fas ligand explains lack of cytolytic activity under physiological conditions. 2003 J. Biol. Chem. 278(18):16183-88.
  • Micheau O*., Lacours S*., Hammann A., Drouineaud V., Tschopp J., Solary E., Dimanche-Boitrel M.T. Chemotherapy enhances TNF-related apoptosis-inducing Ligand DISC assembly in HT29 human colon cancer cells. 2003 Oncogene, 22(12): 1807-1816. Equal contribution*.
  • Legler D.F., Micheau O., Doucey M.A., Tschopp J., Bron C. Lipid rafts are essential for TNF±-mediated TNFR1/RIP ubiquitination and NF-kB activation. 2003 Immunity.18(5):655-64 .
  • Micheau O., Thome M., Schneider P., Holler N., Tschopp J., Nicholson D., Briand C., Grutter M.G.The long form of FLIP is an activator of Caspase-8 at the Fas death-inducing signaling complex. 2002 J. Biol. Chem. 277(47):45162-71.
  • Sordet O, Rébé C, Plenchette S, Zermati Y, Hermine O, Vainchenker W, Garrido C, Solary E, Dubrez-Daloz L. Specific involvement of caspases in the differentiation of monocytes into macrophages. Blood. 2002 Dec 15;100(13):4446-53.
  • Vautier D, Karsten V, Egles C, Chluba J, Schaaf P, Voegel JC, Ogier J. Polyelectrolyte multilayer films modulate cytoskeletal organization in chondrosarcoma cells. J Biomater Sci Polym Ed. 2002;13(6):713-32.
  • Tryoen-Toth P, Vautier D, Haikel Y, Voegel JC, Schaaf P, Chluba J, Ogier J. Viability, adhesion, and bone phenotype of osteoblast-like cells on polyelectrolyte multilayer films. J Biomed Mater Res. 2002 Jun 15;60(4):657-67.
  • Ducoroy P., Micheau O., Dubrez-Daloz L., Annat J., de Fornel D., Solary E. LF-15-0195 immunosuppressive agent enhances actvation-induced T-Cell death by facilitating caspase-8 activation at the DISC level. 2002 Blood. 101(1): 194-201.
  • Kovacsovics M., Martinon F., Micheau O., Bodmer JL., Hofmann K. and Tschopp J. Overexpression of Helicard, a CARD-Containing Helicase Cleaved during Apoptosis, Accelerates DNA Degradation. 2002 Cur. Biol., 12(10):838-843.
  • Chluba J, Voegel JC, Decher G, Erbacher P, Schaaf P, Ogier J. Peptide hormone covalently bound to polyelectrolytes and embedded into multilayer architectures conserving full biological activity. Biomacromolecules. 2001 Fall;2(3):800-5.
  • Chluba J, Lima de Souza D, Frisch B, Schuber F. Enhancement of gene delivery by an analogue of alpha-MSH in a receptor-independent fashion. Biochim Biophys Acta. 2001 Feb 9;1510(1-2):198-208.
  • Simonin F, Slowe S, Becker JA, Matthes HW, Filliol D, Chluba J, Kitchen I, Kieffer BL. Analysis of [3H]bremazocine binding in single and combinatorial opioid receptor knockout mice. Eur J Pharmacol. 2001 Mar 2;414(2-3):189-95.
  • Micheau O., Lens S., Gaide O., Alevizopoulos K., Tschopp J. NF-kappaB Signals Induce the Expression of c-FLIP. 2001 Mol. Cell. Biol. 21(16):5299-5305.
  • Gaide O, Martinon F, Micheau O, Bonnet D, Thome M, Tschopp J. Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation. 2001 FEBS Lett. 496(2-3):121-127.
  • Kataoka T, Holler N, Micheau O, Martinon F, Tinel A, Hofmann K, Tschopp J. Bcl-rambo, a novel Bcl-2 homologue that induces apoptosis via its unique C-terminal extension. 2001 J. Biol. Chem. 276(22):19548-19554.
  • Thome M., Gaide O., Micheau O., Martinon F., Bonnet D., Gonzalez M., Tschopp J. Equine Herpesvirus Protein E10 Induces Membrane Recruitment and Phosphorylation of its Cellular Homologue, Bcl-10. 2001 J. Cell Biol. 152(5):1115-1122.
  • Solary E, Plenchette S, Sordet O, Rébé C, Ducoroy P, Filomenko R, Bruey JM, Droin N, Corcos L. Modulation of apoptotic pathways triggered by cytotoxic agents. Therapie. 2001 Sep-Oct;56(5):511-8.
  • Plenchette S, Moutet M, Benguella M, N’Gondara JP, Guigner F, Coffe C, Corcos L, Bettaieb A, Solary E. Early increase in DcR2 expression and late activation of caspases in the platelet storage lesion. Leukemia. 2001 Oct;15(10):1572-81.
  • Sordet O, Rébé C, Leroy I, Bruey JM, Garrido C, Miguet C, Lizard G, Plenchette S, Corcos L, Solary E. Mitochondria-targeting drugs arsenic trioxide and lonidamine bypass the resistance of TPA-differentiated leukemic cells to apoptosis. Blood. 2001 Jun 15;97(12):3931-40.
  • Holler N., Zaru R., Micheau O., Thome M., Attinger A., Valitutti S., Bodmer J.L., Schneider P., Seed B., Tschopp J. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule, 2000 Nat. Immunol. 1(6): 449 – 541.
  • Filliol D, Ghozland S, Chluba J, Martin M, Matthes HW, Simonin F, Befort K, Gavériaux-Ruff C, Dierich A, LeMeur M, Valverde O, Maldonado R, Kieffer BL. Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses. Nat Genet. 2000 Jun;25(2):195-200.
  • Rochat-Steiner V, Becker K, Micheau O., Schneider P., Burns K., Tschopp J. FIST/HIPK3: a Fas/FADD interacting serine/threonine kinase that induces FADD phosphorylation and inhibits Fas-mediated Jun N-terminal kinase activation, 2000 J. Exp. Med. 192(8):1165-74.
  • Dimanche-Boitrel M.T., Micheau O., France D., Hammann A., Duchamp O., Genne P., Solary E. P27KiP1 overexpression inhibits the growth and doxorubicin sensitivity of HT29 human colon cancer cells in vivo. 2000 Anticancer Res. 20(2A):849-52.

1987-1999

  • Micheau O., Solary E., Hammann A., Dimanche-Boitrel M.T.,STAT-1-independent upregulation of FADD and procaspase-3 and -8 in cancer cells treated with cytotoxic drugs. 1999 Biochem Biophys Res Commun. 256(3):603-7.
  • Dimanche-boitrel M.T., Micheau O., Solary E. Fas est implique dans l’apoptose induite par les agents anticancereux independamment de toute interaction avec son ligand. 1999 Medecine et Sciences, 15 :895-6.
  • Micheau O., Solary E., Hammann A., Dimanche-Boitrel M.T., Fas-ligand-independent, FADD-mediated activation of the Fas death pathway by anticancer drugs, 1999 J. Biol. Chem. 274(12):7987-92.
  • Solary E., Micheau O., Martin F., Dimanche-Boitrel M.T., Martin F., Le systeme Fas/Fas ligand: implication dans la reponse immunitaire antitumorale et la resistance aux agents cytotoxiques, 1998 Bulletin du Cancer. 85(8):685-94.
  • Dimanche-Boitrel M.T., Micheau O., Hammann A., Haugg M., Eymin B., Chauffert B, Solary E., Contribution of the cyclin-dependent kinase inhibitor p27KIP1 to the confluence-dependent resistance of colon carcinoma HT29 cells. 1998 Int. J. Cancer 77(5):796-802.
  • Bonnotte B., Favre N., Reveneau S., Micheau O., Droin N., Garrido C., Fontana A., Chauffert B., Solary E., Martin F. Cancer cell sensitization to fas-mediated apoptosis by sodium butyrate. 1998 Cell Death Differ. 1998;5(6):480-7.
  • Micheau O., Solary E., Hammann A., Martin F., Dimanche-Boitrel M.T., Sensitization of Cancer Cells Treated With Cytotoxic Drugs to Fas-Mediated Cytotoxicity. 1997 J. Natl. Cancer Inst. 89(11):783-9.
  • Chluba J, Steeg C, Becker A, Wekerle H, Epplen JT. T cell receptor beta chain usage in myelin basic protein-specific rat T lymphocytes. Eur J Immunol. 1989 Feb;19(2):279-84.
  • Hauke G, Epplen JT, Chluba J, Hollmann A, Peter HH. IgD/lambda plasmocytoma with immunoglobulin kappa light-chain genes in the germ-line configuration. J Clin Immunol. 1988 Sep;8(5):407-13.
  • Sun D, Qin Y, Chluba J, Epplen JT, Wekerle H. Suppression of experimentally induced autoimmune encephalomyelitis by cytolytic T-T cell interactions. Nature. 1988 Apr 28;332(6167):843-5.
  • Chluba J, Becker A, Epplen JT. A homologous beta-chain variable element in rat, mouse, and human T-cell receptors. Immunogenetics. 1988;28(4):292-4.
  • Epplen JT, Chluba J, Hardt C, Hinkkanen A, Steimle V, Stockinger H. Mammalian T-lymphocyte antigen receptor genes: genetic and nongenetic potential to generate variability. Hum Genet. 1987 Apr;75(4):300-10.